BIOTUNE

The Applications of BioTune Therapy

In ancient times sound and vibration were considered important aspects of healing as observed in chanting, and prayers. The earliest known use of the vibrotactile method for healing can be dated back to 40,000 years whence the didgeridoo, a wind instrument, was used to heal muscle tears and illnesses but there is a resurgence and return to our indigenous ways. Vibroacoustic Therapy Referred to VAT which is the therapy and technology BioTune provides has been used in hospitals since the 1970s and is becoming a mainstream approach to health and wellness.

In 1928 Erwin Schliepe discovered that short sound waves accelerated healing in cancer patients. It was Olav Skille who in 1968 developed the equipment and music software that delivered the vibrotactile input to individuals suffering from Rett syndrome. This was further researched by Tony Wigram in the 1990s and thus the research and evidence from neuroscience have brought music and vibrotactile therapy into the circle of holistic medicine.

BioTune

BioTune is a wellness and meditation platform that combines sound, and vibration technology (VAT) with the BioTune app, providing effortless meditation and wellness.
The BioTune app makes meditation simple and effective by providing four categories of mental states that can be nurtured: relaxation, focus, energize, and transformation. The content in each category has been designed for maximum effectiveness through the verification process on test subjects with EEG and HRV and their baseline and response measures.
BodyWaves ™ are subsonic frequencies tuned to specific brainwaves which provide entrainment through immersive whole-body vibrations coupled with soundscapes to keep the experience engaging and soothing.

The programs range from 15 minutes to 90 minutes.
BioTune has several products to fit the needs of individuals and applications:
1. VBR8 Headphones incorporating vibration and tactile for an immersive experience.

2. VBR8 Massage Table for practitioners.

3. VBR8 Yoga Mats which are designed to be used in meditation and yoga studios.

4. VBR8 Chair for offices and production studios.

Various medical application in which BioTune Therapy is used

Relaxation and stress reduction

Biotune Therapy helps in relaxing and decreasing stress levels for patients undergoing diagnostic imaging. (Weaver et al., 2020)
30 min VAT sessions, once a week for 3 weeks for dimentia patients reduces anxiousness, pain, heart rate and blood pressure (Brennan, 2018)
20 min VAT session causes 55% reduction in perceived stress among university students (Kantor et. al. 2022)

Pain Relief

22 minutes VAT session reduces pain and symptoms of tension, fatigue, headache and nausea by 53% (G. Patrick, 1999)
7 days of VAT relieves pain in laryngeal cancer patients by up to 95.6% being significantly greater than the non-therapy group (Xi, 2005)
Evaluation of 41 sessions of the therapy revealed a 61% to 74% decrease in pain and symptoms in cancer patients (Brewer & Coope, 2003)
Patients with rheumatoid arthritis experienced a 64% reduction in perception of pain when different frequencies of vibrations were transmitted on pain receptors (Chesky & Michel, 1991)
20 minutes sessions of VAT for 10 days in children with juvenile arthritis reduces pain and swelling of joints by 60% and 76%, respectively. (Ailioaie et. al. 2011)
30 minutes session of VAT 4 times a day over 240 days in a patient of refractory postherpetic neuralgia reduces 50% of the pain (Wang et. al. 2021).
43% of the patients with Ehlers-Danlos Syndrome, experience a marked decrease in perception of pain after VAT therapy (Vuong et. al. 2020).

Recovery and Rejuvenation

Circulation

50HZ VAT therapy produces an increase skin blood flow (SBF) (Colleen Maloney-Hinds et al., 2008)
Sound wave therapy 3 to 5 times a week for 30 minutes promotes the well-being of frail elderly subjects by increasing blood circulation as evident by relatively higher skin temperature during the sessions. (Zheng et al., 2009)
15 to 30 minutes VAT session in patients undergoing elective surgeries reduces stress, anxiety and pain by 50%. received 50% reduction in stress and pain by undergoing 15-30 min VAT session (Nilsson, 2008)

Reducing Blood Pressure

In 60 to 70% of people, VAT session decreases blood pressure and pulse rate by up to 15 and 10 points, respectively, thereby preventing risks of cardiovascular and cerebral diseases (Takahashi & Matsushita, 2006)
With a 20 minutes long session of VAT preceded and followed by a 5 minutes period of silence, a relaxing trend occurs in the heart rate and blood pressure due to the stimulation of the Parasympathetic Nervous System, responsible for generating a relaxing response in the body (Delmastro, et. al. 2018).

Mental health

Depression

VAT for 30 minutes every day for 2 consecutive weeks decreases symptoms of depression and sadness by 11%. (Koike et. al. 2012)
8 sessions of 20 minutes of low-frequency music impulse stimulation causes reduction of depression symptoms by more than 70% (Sigurdardóttir et al., 2019)
30 min session, 5 days per week, over 5 weeks reduces depression by 62%, and improves sleep quality, quality of life and anhedonia by up to 37%, 43%, and 80% respectively (Braun Janzen et al., 2019)

Autism

20 minutes sessions of Vibroacoustic Therapy twice weekly for 5 weeks reduces self-injurious, stereotypic, and aggressive destructive behaviors in the autism patients (Lundqvist et al., 2009)
Therapy may help children with ASD to improve their skills such as social interaction, verbal communication, initiating behavior, and social‐emotional reciprocity. It may also help to enhance non‐verbal communication skills. Furthermore, it may contribute to increasing social adaptation skills in children with ASD and promoting the quality of parent‐child relationships (Geretsegger et al., 2014)

Elderly Care

Sound wave therapy 3 to 5 times a week for 30 minutes promotes the well-being of frail elderly subjects via improved functional capacity, increased blood circulation to the skin, and decreased bone metabolism as evident by the increase in daily walking kilometers by 3 meters, bone density by 6%, fall in blood cholesterol by 8% and low density lipoprotein levels by 13% (Zheng et al., 2009)

Fibromyalgia

Delta-embedded music, pulsating regularly within the 0.25 Hz to 4 Hz frequency band of brain wave activity, is a potential alternative therapy for fibromyalgia and fibromyalgia-associated sleep disturbances (Picard et al., 2014)
75% of fibromyalgia patients start using a reduced dosage of painkillers after 23 minutes’ VAT sessions twice a week for 5 weekswhile 25% stopped using painkillers completely. It also improves the range of movement of neck muscles to up to 75% (Naghdi et al., 2015)

Alzheimer’s Disease

30 minutes session of 40 Hz sound stimulation twice a week for over 6 weeks increases cognition, alertness, awareness of the surroundings, interaction, and storytelling abilities in patients with mild and moderate Alzheimer’s disease (Clements-Cortes et al., 2016)

Parkinson’s Disease

Whole body random unsynchronized vibrations of around 6 Hz delivered to the feet in 5 series of sessions each lasting for 1 minute with 1 minute rest periods in between decreases tremors by 25%, rigidity by 24%, bradykinesia by 12% and improves gait and posture problems by 15%. (Hass et al., 2006)
76% of the patients who receive Physioacoustic Therapy (PAT) at 40Hz for 12 weeks observe improvement in overall motor symptoms of the disease like tremor, rigidity, bradykinesia, and posture and gait as depicted by an increase of minimum 5 points in UPDRS motor score meant for Parkinson’s patients (Mosabbir & Ahonen, 2020)

Sleep: Improving Sleep, Helping with Insomnia

One month of Vibroacoustic stimulation therapy in insomnia patients increases sleep time by an average of 30.6 minutes per night, and the severity of insomnia also decreases as 64% of patients observe a decrease in the Insomnia Severity Index score after the therapy (Zabrecky et al., 2020)
Improves sleep quality and physical and mental state as people receiving VAT therapy has lower scores for daytime functional disturbances as compared to the control group (Kong et al., 2006)

References

Aalbers, S., Fusar‐Poli, L., Freeman, R., Spreen, M., Ket, J., Vink, A., Maratos, A., Crawford, M., Chen, X., & Gold, C. (2017). Music therapy for depression. Cochrane Database of Systematic Reviews, 11. https://doi.org/10.1002/14651858.CD004517.pub3

Ailioaie, L. M., Ailioaie, C., Ancuta, C., & Chirieac, R. (2011). EFFECTS OF PHYSICAL AND VIBROACOUSTIC THERAPY IN CHRONIC PAIN IN JUVENILE ARTHRITIS. Romanian Journal of Rheumatology, 20(3).

Braun Janzen, T., Shirawi, M., Rotzinger, S., Kennedy, S., & Bartel, L. (2019). A Pilot Study Investigating the Effect of Music-Based Intervention on Depression and Anhedonia. Frontiers in Psychology, 10, 1038. https://doi.org/10.3389/fpsyg.2019.01038

Brennan, F. M. (2018). The Role of Entrainment on an Older Adult’s Stress and Anxiety: A Mixed Methods Study (Doctoral dissertation, Molloy College).

Brewer, C., & Coope, V. (2003). Effectiveness of vibroacoustic music for pain and symptom management in outpatient chemotherapy treatment. Proceedings of the First International Institute on the Arts in Healing, Boca Raton, FL.

Chesky, K. S., & Michel, D. E. (1991). The Music Vibration Table (MVTTM): Developing a Technology and Conceptual Model for Pain Relief. Music Therapy Perspectives, 9(1), 32–38. https://doi.org/10.1093/mtp/9.1.32

Clements-Cortes, A., Ahonen, H., Evans, M., Freedman, M., & Bartel, L. (2016). Short-Term Effects of Rhythmic Sensory Stimulation in Alzheimer’s Disease: An Exploratory Pilot Study. Journal of Alzheimer’s Disease, 52(2), 651–660. https://doi.org/10.3233/JAD-160081

Colleen Maloney-Hinds, Jerrold Scott Petrofsky, & Grenith Zimmerman. (2008). The effect of 30 Hz vs. 50 Hz passive vibration and duration of vibration on skin blood flow in the arm. Medical Science Monitor, 14(3), 112–116.

Delmastro, F., Di Martino, F., & Dolciotti, C. (2018, March). Physiological impact of vibro-acoustic therapy on stress and emotions through wearable sensors. In 2018 ieee international conference on pervasive computing and communications workshops (percom workshops) (pp. 621-626). IEEE.

G. Patrick. (1999). The effects of vibroacoustic music on symptom reduction. IEEE Engineering in Medicine and Biology Magazine, 18(2), 97–100. https://doi.org/10.1109/51.752987

Geretsegger, M., Elefant, C., Mössler, K., & Gold, C. (2014). Music therapy for people with autism spectrum disorder. Cochrane Database of Systematic Reviews, 6. https://doi.org/10.1002/14651858.CD004381.pub3

Gold, K. (2014). But does it do any good? Measuring the impact of music therapy on people with advanced dementia: (Innovative practice). Dementia, 13(2), 258–264. https://doi.org/10.1177/1471301213494512

Haas, Christian T., et al. "The effects of random whole-body-vibration on motor symptoms in Parkinson's disease." NeuroRehabilitation 21.1 (2006): 29-36.

Kantor, J., Vilímek, Z., Vítězník, M., Smrčka, P., Campbell, E. A., Bucharová, M., ... & Kantorová, L. (2022). Effect of low frequency sound vibration on acute stress response in university students—Pilot randomized controlled trial. Frontiers in Psychology, 6293.

Kim, H. H. (2015). Effects of experience-based group therapy on cognitive and physical functions and psychological symptoms of elderly people with mild dementia. Journal of physical therapy science, 27(7), 2069-2071.

King, L. K., Almeida, Q. J., & Ahonen, H. (2009). Short-term effects of vibration therapy on motor impairments in Parkinson’s disease. NeuroRehabilitation, 25(4), 297–306. https://doi.org/10.3233/NRE-2009-0528

Koike, Yoshihisa, et al. "Effects of vibroacoustic therapy on elderly nursing home residents with depression." Journal of Physical Therapy Science 24.3 (2012): 291-294.

Kong, J., Liu, W., & Han, B. (2006). Study on release sleep disturbance with vibroacoustic therapy. 21, 1107–1109.

Leuk, J. S. P., Low, L. L. N., & Teo, W.-P. (2020). An Overview of Acoustic-Based Interventions to Improve Motor Symptoms in Parkinson’s Disease. Frontiers in Aging Neuroscience, 12. https://www.frontiersin.org/articles/10.3389/fnagi.2020.00243

Lundqvist, L.-O., Andersson, G., & Viding, J. (2009). Effects of vibroacoustic music on challenging behaviors in individuals with autism and developmental disabilities. Research in Autism Spectrum Disorders, 3, 390–400. https://doi.org/10.1016/j.rasd.2008.08.005

Macerollo, A., Palmer, C., Foltynie, T., Korlipara, P., Limousin, P., Edwards, M., & Kilner, J. M. (2018). High-frequency peripheral vibration decreases completion time on a number of motor tasks. European Journal of Neuroscience, 48(2), 1789–1802. https://doi.org/10.1111/ejn.14050

Mosabbir, A., & Ahonen, H. (2020). Long term effects of physioacoustic vibrations on motor impairments in Parkinson’s disease: A Double-Blinded Randomized Control Trial. https://doi.org/10.3390/healthcare8020113

Naghdi, L., Ahonen, H., Macario, P., & Bartel, L. (2015). The Effect of Low-Frequency Sound Stimulation on Patients with Fibromyalgia: A Clinical Study. Pain Research and Management, 20, 375174. https://doi.org/10.1155/2015/375174

Nilsson, U. (2008). The Anxiety- and Pain-Reducing Effects of Music Interventions: A Systematic Review. AORN Journal, 87(4), 780–807. https://doi.org/10.1016/j.aorn.2007.09.013

Pavlicevic, M., Tsiris, G., Wood, S., Powell, H., Graham, J., Sanderson, R., Millman, R., & Gibson, J. (2015). The ‘ripple effect’: Towards researching improvisational music therapy in dementia care homes. Dementia, 14(5), 659–679. https://doi.org/10.1177/1471301213514419

Picard, L. M., Bartel, L. R., Gordon, A. S., Cepo, D., Wu, Q., & Pink, L. R. (2014). Music as a Sleep Aid in Fibromyalgia. Pain Research and Management, 19, 272108. https://doi.org/10.1155/2014/272108

Sandler, H., Fendel, U., Buße, P., Rose, M., Bösel, R., & Klapp, B. F. (2017). Relaxation – Induced by Vibroacoustic Stimulation via a Body Monochord and via Relaxation Music – Is Associated with a Decrease in Tonic Electrodermal Activity and an Increase of the Salivary Cortisol Level in Patients with Psychosomatic Disorders. PLOS ONE, 12(1), e0170411. https://doi.org/10.1371/journal.pone.0170411

Sigurdardóttir, G., Nielsen, P., Rønager, J., & Wang, A. (2019). A pilot study on high amplitude low frequency–music impulse stimulation as an add‐on treatment for depression. Brain and Behavior, 9. https://doi.org/10.1002/brb3.1399

Takahashi, T., & Matsushita, H. (2006). Long-Term Effects of Music Therapy on Elderly with Moderate/Severe Dementia. Journal of Music Therapy, 43(4), 317–333. https://doi.org/10.1093/jmt/43.4.317

Vuong, V., Mosabbir, A., Paneduro, D., Picard, L., Faghfoury, H., Evans, M., ... & Bartel, L. (2020). Effects of rhythmic sensory stimulation on ehlers–danlos syndrome: a pilot study. Pain Research and Management, 2020.

Wang, X., Ye, J., Yang, B., & Xiang, J. (2021). Low frequency sound stimulation greatly improved the outcome of a refractory postherpetic neuralgia patient with mood and sleep disorder: a case report. Annals of Palliative Medicine, 10(10), 11221-11225.

Weaver, C., Dwiggins, A., Frye, S., Hardy, A., Botkin, C., Muzaffar, R., & Osman, M. (2020). Rhythmic Entrainment: A Music Therapy Intervention to Elicit Relaxation and Decrease Anxiety Prior To Diagnostic Imaging. Journal of Nuclear Medicine, 61(supplement 1), 3024.

Xi, A. (2005). Application of Vibroacoustic Therapy in the Nursing Care of Postopera tive Pain Relief in Patients with Laryngeal Cancer.

Zabrecky, G., Shahrampour, S., Whitely, C., Alizadeh, M., Conklin, C., Wintering, N., Doghramji, K., Zhan, T., Mohamed, F., Newberg, A., & Monti, D. (2020). An fMRI Study of the Effects of Vibroacoustic Stimulation on Functional Connectivity in Patients with Insomnia. Sleep Disorders, 2020, 7846914. https://doi.org/10.1155/2020/7846914

Zheng, A., Sakari, R., Cheng, S., Hietikko, A., Moilanen, P., Timonen, J., Fagerlund, K., Kärkkäinen, M., Alèn, M., & Cheng, S. (2009). Effects of a low-frequency sound wave therapy programme on functional capacity, blood circulation and bone metabolism in frail old men and women. Clinical Rehabilitation, 23(10), 897–908. https://doi.org/10.1177/0269215509337273

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